Table 4.

Binding characteristics of receptors for IGF-I in membranes of Caki-I renal adenocarcinomas after in vivo treatment with GH-RH antagonist MZ-4-71

Treatment group	Kd, nM	Bmax, fmol/ mg protein
Control	0.89  ± 0.08	126.3  ± 5.9
MZ-4-71	0.49  ± 0.14	71.5  ± 8.85*

Binding characteristics were obtained from 10-point displacement experiments. Significance was calculated with Duncan’s new multiple range test. All values represent mean ± SEM of 2 or 3 experiments, each done in triplicate. ∗, P < 0.05 vs. control.