Figure 1.

Features of human positionally cloned disease gene products. The vertical axis in each panel indicates the percentage of the analyzed protein set. (A) Protein size classes. 1, Positionally cloned disease gene products; 2, human proteins from swiss-prot. (B) Domain organization. 1, Positionally cloned disease gene products; 2, human proteins from swiss-prot. The horizontal axis indicates the predicted globular domains, with the lower size limit of 20 amino acid residues. (C) Sequence conservation. 1, All sequence similarities; 2, orthologs.