Figure 3.

ADPR cyclase activity in extracts from brain cortex, skeletal muscle, liver, and uterus of E₂-treated rats (E₂, solid bars) as compared with controls (C, open bar) and the effect of administration of E₂ (0.2 mg/kg per day) together with tamoxifen (8 mg/kg per day) (E₂ + TXF, shaded bar) for 7 days upon ADPR-cyclase activity in uterus. The activity was determined with NGD as substrate. ∗, Denotes value significantly different (P < 0.01, t test) from uteri of both control (C) and E₂ + TXF-treated rats). Each bar denotes mean ± SEM, n = 3–4 experiments.