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Insulin induces FKHR turnover through proteasomal degradation. (A and B) HepG2 cells were serum-starved for 12 h and treated with 100 nM insulin (A), with or without a proteasome inhibitor MG132 (B), for the indicated periods. Whole cell extracts were analyzed by immunoblotting. (C) HepG2 cells were serum-starved for 12 h and treated with insulin in the presence or absence of indicated proteasome inhibitors for 12 h. Whole cell extracts were analyzed by immunoblotting.
