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The potentiation associated with the final HFS in Fig. 1 is not due to reversal of the ω-CgTX-induced depression of the pEPSP. (A) ω-CgTX-induced depression does not reverse spontaneously over the 40-min duration after application in Fig. 1 (n = 3, average shown). (B and C) ω-CgTX-induced depression does not reverse with HFS in the presence of APV, which blocks LTP induction, either in a single slice (B) or for the group average (C, n = 4).
