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REST trans-activates transcription through binding to NRSE. Activation of transcription by NRSE was compared after cotransfection with the CMV-TSER plasmid expressing a REST antisense mRNA or with the expression plasmids carrying no cDNA. The activity of the NRSE-TATA plasmid is compared with that of TATA-plasmid cotransfected with the same expression plasmid set to 1.
