Table 1.
Anatomical localization of the β-gal-stained cells in transgenic mice constructed with wild-typed (WT) 1,163-bp promoter of the nAChR β2-subunit gene and T1–T10 (same length of promoter point mutated in NRSE).
| Structures | WT | T1 | T2 | T3 | T4 | T5 | T6 | T7 | T8 | T9 | T10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cortex | — | ± | + | + | + | — | ± | ± | ± | ± | + |
| Superior colliculus | + | ± | + | + | + | + | + | — | + | + | + |
| Thalamus | + | — | ± | — | — | — | — | — | — | — | — |
| Mesencephalon | + | — | — | — | — | — | — | — | — | — | — |
| Hypothalamus | ± | — | — | — | — | — | — | — | — | — | — |
| Basal telencephalon | ± | — | — | — | — | — | — | — | — | — | ± |
| Spinal cord | ± | ± | — | — | — | — | — | — | — | — | — |
| Brain stem | + | — | ± | — | — | — | — | — | — | ± | + |
| Otic ganglion | + | — | — | — | — | — | — | — | — | — | — |
| Eighth ganglion | + | — | — | — | — | — | + | — | — | + | + |
| Superior cervical ganglion | + | ± | — | — | — | — | — | — | — | — | — |
| Dorsal root ganglion | + | ± | — | — | — | — | — | — | — | — | — |
| Trigeminal ganglion | ± | — | — | — | — | — | — | — | — | — | ± |
| Cartilage (vertebra) | — | ± | — | — | — | — | — | — | — | + | — |
| Mouth mucosa | — | — | + | — | — | — | — | — | — | + | + |
Mice T9 and T10 have stably integrated the transgene. —, no staining.