Table 2. Virological and histological markers in liver biopsies.

		Virological markers			Histological markers
Animal	Weeks p.i.	ISH*	cccDNA†	RI†	CD3‡	Apoptosis§	PCNA¶
WC377	-4	0	0	0	3	6	40
	4	>95	11	280	3	8	20
	8	>95	33	1,700	16	59	70
	12	24	1	22	40	1,000	160
	16	<0.01	<1	<10	5	2	7
WC378	-4	0	0	0	2	3	2
	4	>95	12	600	3	22	1
	8	>95	28	1,600	36	158	120
	12	<0.01	<1	<10	13	50	10
	16	<0.01	<1	<10	11	4	160
WC380	-4	0	0	0	1	18	7
	4	>95	6	120	3	5	1
	8	>95	61	720	17	34	1
	12	49	13	400	24	140	80
	16	<0.01	<1	<10	5	12	7

^*In situ hybridization for viral nucleic acids, percentage of hepatocytes positive.

^†Molecules per total liver cells by Southern blot assay; RI, replicative intermediates.

^‡Positive cells per 100 hepatocytes (fields containing 3,500-7,700 hepatocytes scored).

^§Apoptotic hepatocytes per 10,000 hepatocytes (1,080-5,000 hepatocytes scored).

^¶Positive hepatocytes per 10,000 hepatocytes (5,440-20,520 hepatocytes scored).