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DDR1-null SMCs produced no MMP-9 activity and less MMP-2 activity compared with wild-type cells. Gelatin zymogram containing conditioned media from wild-type (DDR1+/+) or DDR1-null SMCs (DDR1–/–) plated on wells precoated with 0, 100, or 1000 nM type I collagen. MMP-9A, MMP-9 active; MMP-2L, MMP-2 zymogen; MMP-2A, MMP-2 active.
