Figure 7.

Intimal area was significantly decreased after injury of the DDR1-null mouse carotid compared with wild-type. (a) Cross-sectional area of intima measured 14 days after carotid injury. (b) Cross-sectional area of media measured 14 days after carotid injury. ^AIntimal area in DDR1–/– mice was significantly less than intimal area in wild-type mice. (n = 6 and 8 for DDR1+/+ and DDR1–/– groups, respectively.) (c) There was less collagen deposition in the carotid arterial intima of the DDR1-null mouse. Picrosirius red staining and polarized light microscopy were used to assess the deposition of birefringent collagen in the vessel wall. ×400.