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. 2001 Mar 15;107(6):R37–R45. doi: 10.1172/JCI11297

Figure 4.

Figure 4

Serum concentrations of antigen-specific immunoglobulins in animals immunized with DNP-KLH. CCR6–/– (n = 7; circles) and CCR6+/+ (n = 7; squares) mice were immunized subcutaneously with 30 μg of DNP-KLH in CFA and boosted twice with 30 μg of DNP-KLH in IFA at days 10 and 28 postimmunization. Mice were bled from the retro-orbital plexus at days 7 and 14, then every 21 days, and serum concentration of DNP-KLH–specific Ig isotypes were determined using ELISA. Individual data from the 10–3 dilution and the mean value for each group are presented. Two-tailed t-test value for the IgG2b data at day 35 is P = 0.0032; P > 0.05 for the rest.