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. 1998 Jul 7;95(14):7876–7881. doi: 10.1073/pnas.95.14.7876

Figure 4.

Figure 4

Similarities of the type II B′ core and the type IA domain I. (a) Folding diagrams of DNA topoisomerase I domain I and the DNA topoisomerase II B′ domain. The position of the acidic quartet of amino acids is marked by spheres. The DNA topoisomerase II B′ domain has an additional small β-strand (drawn in light gray) that lies at the edge of the overall fold. (b) Wire stereo diagram [ribbons (50)] showing the superposition of the two domains; DNA topoisomerase I is orange and DNA topoisomerase II blue. The Cα positions of the acidic residues are shown as red (DNA topoisomerase I) and green (DNA topoisomerase II) spheres.