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The biosynthesis of purine nucleoside monophosphates from aminoimidazole carboxamide riboside monophosphate. The present pathways are indicated by solid arrows. The dotted arrow shows a one-step pathway for the synthesis of GMP, instead of the present three-step pathway. A two-step pathway through XMP is also possible. The shorter routes would be expected if GMP, or guanine, was used when the pathways developed.
