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Crosstalk between cPLA2 and sPLA2 in eliciting AA mobilization in activated P388D1 macrophages. PAF activation of the LPS-primed macrophages triggers the “fast” activation of the cPLA2 intracellularly, which in turn allows the “slow” action of sPLA2 at the plasma membrane. The AA liberated by the sPLA2 can be taken up and utilized by COX-2 to generate prostaglandins such as PGE2. For further details see text.
