Table 1.

BRCA1 or BRCA2 germline mutations in Indonesian women with early onset breast cancer

Patient	Agea	gene	Exon	Mutationb	mutation type	Pathogenic mutation	BICc
AE	25	BRCA1	11	c.2784_2785insT	frameshift	+	no
B10	31	BRCA1	13	p.Leu1415X	nonsense	+	no
AA	40	BRCA1	13–15	−d	large rearrangement	+	no
AB	34	BRCA2	11	c.3040_3043del4	frameshift	+	1
B5	66	BRCA2	11	p.Glu2183X	nonsense	+	no
B6	65	BRCA2	11	p.Glu2183X	nonsense	+	no
B-III-5	30	BRCA2	11	p.Leu824X	nonsense	+	no
AZ	40	BRCA2	11	p.Leu824X	nonsense	+	no
W-II	37	BRCA2	21	p.Gln2894X	nonsense	+	no
Q-II	40	BRCA1	2	c.101–10T>C	IVS	±	6
P-III-19	19	BRCA1	9	p.Val191Ile	Missense	±	6
J22	32	BRCA1	11	p.Leu1209Val	Missense	?	no
AZ	40	BRCA1	16	p.Met1652Ile	Missense	±	35
B1	24	BRCA1	20	c.5313–31A>G	IVS	?	no
B7	31	BRCA1	24	p.Arg1835Gln	Missense	?	no
216	33	BRCA1	24	p.Thr1852Ile	Missense	?	no
P-III-19	19	BRCA2	5	p.Gln147Arg	Missense	±	6
B3	24	BRCA2	10	p.Gln609Glu	Missense	?	no
C-II-7	39	BRCA2	11	p.Met1149Val	Missense	±	5
AO	28	BRCA2	11	p.Met1149Val	Missense	±	5
AQ	44	BRCA2	11	p.Met1149Val	Missense	±	5
BH	38	BRCA2	11	p.Met1149Val	Missense	±	5
172	36	BRCA2	11	p.Gln699Leu	Missense	?	no
J32	29	BRCA2	11	p.Arg2108Cys	Missense	±	16
J6	33	BRCA2	11	p.Val950Ile	Missense	?	no
206	37	BRCA2	25	c.9485–16T>C	IVS	±	4
BC	35	BRCA2	27	p.Ile3412Val	Missense	±	109
166	33	BRCA2	27	p.Ile3412Val	Missense	±	109
J24	35	BRCA2	27	p.Ile3412Val	Missense	±	109
206	37	BRCA2	27	p.Lys3326X	nonsense	±	289

^aAge at time of diagnosis

^bGen Bank Accession number, BRCA1: U14680, BRCA2: U43746

^cnumber of times reported in BIC

^dnot determined, detected by MLPA