Table 2 Summary of nine studies on glioma and use of wireless telephones.
Study | Period covered | Study type | Age (years) | Tumour type | No. of cases | OR* (95% CI) | Comments | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Inskip et al 2001, USA5 | 1994–1998 | Case–control | ⩾18 | Glioma | 11 | 0.6 (0.3 to 1.4) | ⩾5 years of cell phone use | |||||||
Auvinen et al 2002, Finland7 | 1996 | Case–control, register‐based | 20–69 | Glioma | 119 | 1.5 (1.0 to 2.4) | Analogue and digital cell phone “ever” use | |||||||
40 | 2.1 (1.3 to 3.4) | Analogue cell phone “ever” use | ||||||||||||
11 | 2.4 (1.2 to 5.1) | Analogue cell phone use 1–2 years | ||||||||||||
11 | 2.0 (1.0 to 4.1) | Analogue cell phone use, >2 years | ||||||||||||
Lönn et al 2005, Sweden Interphone10 | 2000–2002 | Case–control | 20–69 | Glioma | 214 | 0.8 (0.6 to 1.0) | Regular use | |||||||
15 | 1.6 (0.8 to 3.4) | ⩾10 years since first “regular” cell phone use on same side of head as tumour | ||||||||||||
11 | 0.7 (0.3 to 1.5) | ⩾10 years since first “regular” cell phone use on opposite side of head as tumour. | ||||||||||||
Christensen et al 2005 Denmark Interphone12 | 2000–2002 | Case–control | 20–69 | Low‐grade glioma | 47 | 1.1 (0.6 to 2.0) | Regular use | |||||||
6 | 1.6 (0.4 to 6.1) | ⩾10 years since first “regular” use of cell phone | ||||||||||||
High‐grade glioma | 59 | 0.6 (0.4 to 0.9) | Regular use | |||||||||||
8 | 0.5 (0.2 to 1.3) | ⩾10 years since first regular use of cell phone | ||||||||||||
17 ORs for high‐grade glioma, all <1.0, indicate systematic bias. | ||||||||||||||
Hepworth et al 2006 UK Interphone13 | 2000–2004 | Case–control | 18–69 | Glioma | 508 | 0.9 (0.8 to 1.1) | Regular use | |||||||
Not given | 1.6 (0.9 to 2.8) | ⩾10 years of cell phone use on same side of head as tumour. | ||||||||||||
Not given | 0.8 (0.4 to 1.4) | >10 years of cell phone use on opposite side of head as tumour. | ||||||||||||
Schüz et al 2006 Germany Interphone14 | 2000–2003 | Case–control | 30–59 (2000–2001), 30–69 (2001–2003) | Glioma | 138 | 1.0 (0.7 to 1.3) | Regular use | |||||||
12 | 2.2 (0.9 to 5.1) | ⩾10 years since first “regular” use of cell phone | ||||||||||||
30 | 2.0 (1.1 to 3.5) | Female regular use of cell phone (glioma, high‐grade) | ||||||||||||
Hardell et al 2006b, Sweden16 | 1997–2003 | Case–control | 20–80 | Glioma, high‐grade | 281 | 1.4 (1.1 to 1.8) | >1‐year latency of cell phone use | |||||||
71 | 3.1 (2.0 to 4.6) | >10‐year latency of cell phone use | ||||||||||||
39 | 5.4 (3.0 to 9.6) | >10‐year latency of ipsilateral cell phone use | ||||||||||||
23 | 2.2 (1.3 to 3.9) | >10‐year latency of cordless phone use | ||||||||||||
10 | 4.7 (1.8 to 13) | >10‐year latency of ipsilateral cordless phone use | ||||||||||||
Glioma, low‐grade | 65 | 1.4 (0.9 to 2.3) | >1‐year latency of cell phone use | |||||||||||
7 | 1.5 (0.6 to 3.8) | >10‐year latency of cell phone use | ||||||||||||
2 | 1.2 (0.3 to 5.8) | >10‐year latency of ipsilateral cell phone use | ||||||||||||
5 | 1.6 (0.5 to 4.6) | >10‐year latency of cordless phone use | ||||||||||||
3 | 3.2 (0.6 to 16) | >10‐year latency of ipsilateral cordless phone use | ||||||||||||
Schüz et al 2006, Denmark17 | 1982–2002 | Cohort | ⩾18 | Glioma | 257 | SIR = 1.0 (0.9 to 1.1) | No laterality of tumour and mobile phone given | |||||||
54 | SIR = 1.2 (0.9 to 1.6) | Temporal lobe | ||||||||||||
Lahkola et al Denmark, Norway, Finland, Sweden, UK Interphone19 | September 2000–February 2004 (differed between countries) | Case–control | 20–69 (Nordic countries), 18–59 (UK) | Glioma | 867 | 0.8 (0.7 to 0.9) | Regular use | |||||||
77 | 1.4 (1.01 to 1.9) | Ipsilateral mobile phone use, ⩾10 years since first use, p for trend = 0.04 |
SIR, standardised incidence ratio.
*Unless otherwise stated.