Figure 6.
Effect of IL-4–transduced T cells or IL-4–transduced NIH 3T3 cells on the incidence (a), mean percentages of arthritic limbs (b), and mean clinical score (c) of CIA. Mice were immunized with CII on day 0. On day 15, eight mice per group received intraperitoneal injections of 3 × 105 IL-4–transduced DCs, 3 × 106 nontransduced or IL-4–transduced T cells, or 3 × 104 nontransduced or IL-4–transduced NIH 3T3 cells. Control animals were given HBSS. Clinical score was assessed as described in Methods. AP < 0.05 compared with control. BP < 0.01 compared with control.