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. 2001 May 15;107(10):1263–1273. doi: 10.1172/JCI11596

Figure 9.

Figure 9

Hepatic morphology of CBS+/+ and CBS+/– mice fed control diet or high-methionine/low-folate diet. CBS+/+ mice fed control (a) or high-methionine/low-folate diet (c) for 20 weeks. CBS+/– mice fed control (b) or high-methionine/low-folate diet (d) for 16 weeks. The hepatocytes from mice fed the high-methionine/low-folate diet (c and d) are enlarged, multinucleated, and contain extensive microvesicular and macrovesicular lipid with no apparent fibrosis or necrosis. Hematoxylin and eosin staining. ×400.