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. 2001 Jun 1;107(11):1365–1373. doi: 10.1172/JCI11808

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Copyright © 2001, American Society for Clinical Investigation

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Effect of HGF on liver injury. (a) Hematoxylin and eosin staining of liver sections from GVHD mice with or without HGF gene transduction 2 weeks after induction of GVHD. Liver tissue from GVHD control mice showed cellular infiltration in the periportal area (arrow). ×100. (b) Hematoxylin and eosin staining of liver sections from GVHD mice without HGF gene transduction at 2 weeks after induction of GVHD. ×400. (c) Effect of HGF gene transduction on intrahepatic infiltration of mononuclear cells and donor T cells. Liver-infiltrating mononuclear cells were obtained from untreated mice and GVHD mice with or without HGF gene transduction. The number of donor-derived T cells was determined by multiplying the total mononuclear cell count by the H-2K^d–negative and CD3-positive populations. Data are the mean ± SD of five mice. ^AP < 0.05.