Figure 5.

Recombinant IFN-β protein therapy does not result in a significant tumor response. (a) KM12L4 cells were directly injected in the livers of athymic nude mice. On day 5, when tumors were microscopic, animals were randomized to receive daily intraperitoneal injections of PBS or recombinant hIFN-β (1,000 U or 10,000 U). On day 28 animals were sacrificed and sera and livers were harvested for tumor volume measurement. (b) On day 14, when tumors were 3–5 mm³, animals were randomized to receive daily intraperitoneal injections of PBS or recombinant hIFN-β (1,000 U or 10,000 U). On day 28 animals were sacrificed and sera and livers were harvested for tumor volume measurement. Each point represents a single animal, and mean tumor volume is indicated by the large cross.