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Effect of SP600125 on JNK activity in adjuvant arthritis. Rats with adjuvant arthritis were treated with SP600125 or vehicle beginning on day 8 and sacrificed on day 14. The ability of joint lysates to phosphorylate GST-c-Jun was determined as described in Methods. Vehicle-treated rats had high levels of JNK kinase activity, while no activity was detected in the SP600125-treated rats (n = 4 each).
