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Effects of 5-HT on secretin-stimulated fluid secretion. (a) Ducts were stimulated with 1 nM secretin in the presence of HCO3–-CO2. 5-HT (0.1 μM) was added to the bath during stimulation with 1 nM secretin. (b) Concentration-response curve for the effects of 5-HT on secretin-stimulated fluid secretion. The fluid secretory rates are shown as means ± SEM of four experiments. Asterisks indicate significant (P < 0.01) differences.
