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A hypothetical function of 5-HT: a local feedback control of pancreatic duct fluid secretion by the luminal pressure. EC cell–like cells in the duct epithelium are pressure-responsive sensory receptors. The increase in the luminal pressure stimulates the release of 5-HT into interstitium. 5-HT binds to its receptors on the basolateral membrane of the duct cells and inhibits fluid secretion.
