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. 2001 Sep 1;108(5):739–747. doi: 10.1172/JCI12563

Figure 7.

Figure 7

Adoptive transfer studies. (a) Adoptive transfer of wild-type cells into TCR-αβ–/– mice. Splenocytes from wild-type mice were harvested 12 days postimmunization with MOG peptide. The cells were resuspended in PBS and wild-type splenocytes at concentrations of either 100 × 106 (open circles), 50 × 106 (filled triangles), or 25 × 106 (filled squares) were injected intraperitoneally into recipient TCR-αβ–/– mice. The recipients were immunized with MOG peptide 1 day after transfer. Five recipient mice per group were used. (b) Adoptive transfer of splenocytes from STAT4–/– or STAT6–/– mice into TCR-αβ–/– mice. Splenocytes from either wild-type STAT4–/– or STAT6–/– mice were harvested 12 days after immunization with MOG peptide. The cells were resuspended in PBS and 50 × 106 splenocytes from STAT4–/– mice (filled circles) or STAT6–/– mice (filled squares) were injected intraperitoneally into recipient TCR-αβ–/– mice. The recipients were immunized with MOG peptide 1 day after transfer. Five recipient mice per group were used.

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