Table 1.
Ashkenazi Jews (n = 85) | CEPH (n = 60) | African Americans (n = 48) | Chinese Americans (n = 48) | Mexican Americans (n = 48) | ||||||||||||
rs number | SNP Number | SNP name | Position b33a | Position b36.1b | Com Allelec | Min Alleled | mafe | P-value | maf | P-value | maf | P-value | maf | P-value | maf | P-value |
13119 | 1 | C_9270420 | 41373486 | 38718247 | c | t | 0.424 | 0.580 | 0.350 | 0.712 | 0.177 | 0.624 | 0.396 | 0.359 | 0.458 | 0.961 |
748620 | 2 | C_9270421 | 41373037 | 38717798 | c | g | 0.440 | 0.640 | 0.350 | 0.712 | 0.240 | 0.550 | 0.391 | 0.518 | 0.465 | 0.669 |
17599948 | 3 | C_9270454 | 41364175 | 38708936 | a | g | 0.211 | 0.649 | 0.192 | 0.865 | 0.104 | 0.022 | 0.094 | 0.326 | 0.362 | 0.591 |
11653231 | 4 | C_95201 | 41240225 | 38584986 | g | a | 0.435 | 0.703 | 0.350 | 0.712 | 0.240 | 0.550 | 0.396 | 0.359 | 0.467 | 0.905 |
9908805 | 5 | C_3178692 | 41230675 | 38575436 | c | t | 0.008 | 0.948 | 0.375 | 0.878 | 0.011 | 0.941 | ||||
2175957 | 6 | C_11631183 | 41195587 | 38540348 | t | g | 0.447 | 0.665 | 0.350 | 0.712 | 0.250 | 0.441 | 0.396 | 0.359 | 0.446 | 0.935 |
3092986 | 7 | BR1_000340 | 41186761 | 38531522 | a | g | 0.051 | 0.636 | 0.042 | 0.736 | 0.010 | 0.942 | 0.031 | 0.823 | ||
8176072 | 8 | BR1_000392 | 41186709 | 38531470 | t | a | 0.006f | 0.957 | ||||||||
8176074 | 9 | BR1_000571 | 41186530 | 38531291 | g | a | 0.010 | 0.942 | ||||||||
3765640 | 10 | C_2615164 | 41185012 | 38529773 | a | g | 0.440 | 0.640 | 0.350 | 0.712 | 0.228 | 0.740 | 0.394 | 0.433 | 0.444 | 0.592 |
NAg | 11 | M_185delAG | 41184811 | 38529572 | a | - | 0.006 | 0.957 | ||||||||
8176090 | 12 | BR1_007918 | 41179183 | 38523944 | c | g | 0.008 | 0.948 | 0.096 | 0.338 | ||||||
1800062 | 13 | BR1_010574 | 41176528 | 38521289 | g | a | 0.021 | 0.883 | ||||||||
8176101 | 14 | BR1_010796 | 41176306 | 38521067 | a | t | 0.021 | 0.882 | ||||||||
8176103 | 15 | C_2615171 | 41175815 | 38520576 | g | a | 0.463 | 0.291 | 0.350 | 0.712 | 0.234 | 0.640 | 0.396 | 0.359 | 0.458 | 0.961 |
8176104 | 16 | BR1_011340 | 41175762 | 38520523 | g | a | 0.024 | 0.824 | 0.033 | 0.789 | 0.010 | 0.942 | ||||
8176109 | 17 | C_2615172 | 41174541 | 38519302 | a | g | 0.441 | 0.497 | 0.350 | 0.712 | 0.239 | 0.609 | 0.396 | 0.359 | 0.469 | 0.751 |
8065872 | 18 | BR1_016775 | 41170328 | 38515089 | t | a | 0.135 | 0.278 | 0.010 | 0.942 | ||||||
8176120 | 19 | BR1_017105 | 41169998 | 38514759 | g | a | 0.424 | 0.913 | 0.350 | 0.712 | 0.240 | 0.550 | 0.396 | 0.359 | 0.458 | 0.961 |
799914 | 20 | BR1_018573 | 41168546 | 38513307 | g | a | 0.135 | 0.278 | ||||||||
799913 | 21 | BR1_019408 | 41167711 | 38512472 | a | g | 0.032 | 0.772 | 0.042 | 0.736 | 0.365 | 0.813 | 0.010 | 0.942 | ||
8176128 | 22 | BR1_019904 | 41167215 | 38511976 | t | a | 0.063 | 0.644 | ||||||||
8176133 | 23 | BR1_020896 | 41166223 | 38510984 | t | g | 0.422 | 0.738 | 0.350 | 0.712 | 0.167 | 0.488 | 0.396 | 0.359 | 0.458 | 0.961 |
799912 | 24 | C_2615180 | 41165899 | 38510660 | c | t | 0.472 | 0.701 | 0.364 | 0.926 | 0.125 | 0.322 | 0.396 | 0.359 | 0.489 | 0.882 |
799923 | 25 | BR1_026422 | 41160696 | 38505457 | c | t | 0.232 | 0.031 | 0.308 | 0.858 | 0.042 | 0.763 | 0.104 | 0.459 | ||
8176145 | 26 | BR1_029258 | 41157859 | 38502620 | t | c | 0.400 | 0.038 | 0.319 | 0.586 | 0.240 | 0.550 | 0.404 | 0.309 | 0.448 | 0.829 |
8176146 | 27 | BR1_029448 | 41157669 | 38502430 | c | t | 0.031 | 0.774 | 0.008 | 0.948 | ||||||
7503154 | 28 | BR1_030748 | 41156369 | 38501130 | t | g | 0.415 | 0.618 | 0.339 | 0.478 | 0.223 | 0.771 | 0.396 | 0.359 | 0.468 | 0.862 |
1799950 | 29 | BR1_031875 | 41155246 | 38500007 | a | g | 0.077 | 0.442 | 0.042 | 0.736 | 0.010 | 0.942 | 0.031 | 0.823 | ||
4986850 | 30 | BR1_032885 | 41154236 | 38498997 | g | a | 0.133 | 0.096 | 0.113 | 0.071 | 0.033 | 0.819 | 0.013 | 0.935 | ||
16940 | 31 | BR1_033119 | 41154002 | 38498763 | t | c | 0.422 | 0.429 | 0.350 | 0.712 | 0.177 | 0.624 | 0.396 | 0.359 | 0.448 | 0.829 |
799917 | 32 | BR1_033420 | 41153701 | 38498462 | c | t | 0.429 | 0.766 | 0.358 | 0.868 | 0.125 | 0.322 | 0.396 | 0.359 | 0.479 | 0.571 |
4986852 | 33 | BR1_003927 | 41153194 | 38497955 | g | a | 0.012 | 0.912 | 0.042 | 0.736 | 0.010 | 0.942 | ||||
2227945 | 34 | BR1_034226 | 41152895 | 38497656 | a | g | 0.052 | 0.703 | 0.010 | 0.942 | ||||||
16942 | 35 | BR1_034356 | 41152765 | 38497526 | a | g | 0.433 | 0.868 | 0.348 | 0.615 | 0.245 | 0.521 | 0.396 | 0.359 | 0.447 | 0.716 |
799916 | 36 | C_7530109 | 41151955 | 38496716 | t | g | 0.438 | 0.482 | 0.358 | 0.868 | 0.271 | 0.703 | 0.394 | 0.433 | 0.479 | 0.894 |
2070833 | 37 | BR1_035507 | 41151614 | 38496375 | c | a | 0.031 | 0.001 | 0.271 | 0.726 | 0.135 | 0.167 | ||||
2070834 | 38 | BR1_036077 | 41151050 | 38495811 | a | c | 0.435 | 0.626 | 0.342 | 0.568 | 0.250 | 1.000 | 0.396 | 0.359 | 0.438 | 0.634 |
8176158 | 39 | BR1_036793 | 41150334 | 38495095 | a | g | 0.418 | 0.393 | 0.353 | 0.665 | 0.174 | 0.532 | 0.396 | 0.359 | 0.458 | 0.961 |
8176160 | 40 | BR1_036859 | 41150268 | 38495029 | a | g | 0.435 | 0.626 | 0.350 | 0.712 | 0.240 | 0.550 | 0.396 | 0.359 | 0.458 | 0.961 |
8176166 | 41 | BR1_038085 | 41149042 | 38493803 | a | g | 0.196 | 0.391 | 0.150 | 0.172 | 0.104 | 0.022 | 0.120 | 0.632 | 0.344 | 0.395 |
8176174 | 42 | BR1_040350 | 41146777 | 38491538 | a | t | 0.063 | 0.644 | ||||||||
3950989 | 43 | C_3178696 | 41146718 | 38491479 | g | a | 0.441 | 0.566 | 0.348 | 0.615 | 0.234 | 0.640 | 0.396 | 0.359 | 0.457 | 0.923 |
8176175 | 44 | BR1_040669 | 41146458 | 38491220 | t | - | 0.006 | 0.956 | 0.073 | 0.586 | ||||||
8176177 | 45 | BR1_041288 | 41145840 | 38490601 | a | g | 0.021 | 0.883 | ||||||||
8176178 | 46 | BR1_041721 | 41145407 | 38490168 | a | g | 0.042 | 0.763 | ||||||||
1060915 | 47 | C_3178676 | 41143235 | 38487996 | a | g | 0.380 | 0.105 | 0.352 | 0.851 | 0.177 | 0.624 | 0.396 | 0.359 | 0.468 | 0.862 |
3737559 | 48 | C_3178677 | 41143069 | 38487830 | c | t | 0.124 | 0.481 | 0.067 | 0.580 | 0.083 | 0.208 | 0.043 | 0.761 | ||
8176187 | 49 | BR1_045154 | 41141974 | 38486735 | t | c | 0.010 | 0.942 | ||||||||
8176188 | 50 | BR1_045505 | 41141623 | 38486384 | t | g | 0.063 | 0.644 | ||||||||
6416927 | 51 | BR1_0046019 | 41141109 | 38485870 | g | c | 0.083 | 0.208 | ||||||||
8176198 | 52 | BR1_047826 | 41139302 | 38484063 | t | a | 0.422 | 0.429 | 0.362 | 0.427 | 0.348 | 0.114 | 0.426 | 0.761 | 0.479 | 0.571 |
8176199 | 53 | BR1_0477839 | 41139289 | 38484050 | a | c | 0.341 | 0.594 | 0.258 | 0.502 | 0.135 | 0.167 | 0.177 | 0.624 | 0.396 | 0.135 |
4239147 | 54 | BR1_048551 | 41138577 | 38483338 | t | c | 0.440 | 0.640 | 0.324 | 0.677 | 0.271 | 0.703 | 0.394 | 0.433 | 0.452 | 0.711 |
8176206 | 55 | BR1_050244 | 41136885 | 38481646 | a | g | 0.052 | 0.703 | 0.010 | 0.942 | ||||||
2236762 | 56 | C_11621042 | 41135440 | 38480201 | a | t | 0.435 | 0.626 | 0.358 | 0.868 | 0.271 | 0.703 | 0.406 | 0.581 | 0.479 | 0.894 |
1799966 | 57 | C_2615208 | 41131859 | 38476620 | t | c | 0.456 | 0.456 | 0.350 | 0.712 | 0.233 | 0.781 | 0.396 | 0.359 | 0.469 | 0.751 |
3092987 | 58 | BR1_055669 | 41131488 | 38476249 | a | g | 0.416 | 0.545 | 0.350 | 0.712 | 0.170 | 0.510 | 0.396 | 0.359 | 0.458 | 0.961 |
8176225 | 59 | BR1_056796 | 41130361 | 38475122 | g | t | 0.031 | 0.823 | ||||||||
8176232 | 60 | BR1_058369 | 41128788 | 38473549 | c | t | 0.013 | 0.936 | ||||||||
8176234 | 61 | BR1_058614 | 41128545 | 38473306 | a | g | 0.437 | 0.345 | 0.350 | 0.712 | 0.239 | 0.609 | 0.396 | 0.359 | 0.458 | 0.961 |
8176235 | 62 | BR1_058834 | 41128325 | 38473086 | g | a | 0.339 | 0.872 | 0.258 | 0.502 | 0.167 | 0.488 | 0.396 | 0.359 | 0.436 | 0.972 |
8176236 | 63 | BR1_059589 | 41127570 | 38472331 | t | c | 0.008 | 0.948 | 0.359 | 0.556 | 0.010 | 0.942 | ||||
8176240 | 64 | BR1_060022 | 41127137 | 38471898 | t | c | 0.063 | 0.644 | ||||||||
8176242 | 65 | BR1_060520 | 41126639 | 38471400 | g | a | 0.433 | 0.538 | 0.350 | 0.712 | 0.170 | 0.510 | 0.406 | 0.581 | 0.458 | 0.961 |
8176245 | 66 | BR1_061014 | 41126145 | 38470906 | t | c | 0.063 | 0.644 | ||||||||
3092994 | 67 | C_2615220 | 41124590 | 38469351 | c | t | 0.434 | 0.471 | 0.350 | 0.712 | 0.228 | 0.242 | 0.396 | 0.359 | 0.266 | 0.808 |
8176259 | 68 | BR1_062588 | 41124571 | 38469332 | t | - | 0.052 | 0.703 | ||||||||
8176265 | 69 | BR1_0064398 | 41122761 | 38467522 | g | a | 0.417 | 0.477 | 0.350 | 0.712 | 0.167 | 0.729 | 0.394 | 0.433 | 0.260 | 0.848 |
2187603 | 70 | BR1_064501 | 41122658 | 38467419 | g | a | 0.422 | 0.429 | 0.350 | 0.712 | 0.167 | 0.729 | 0.396 | 0.359 | 0.260 | 0.848 |
8176273 | 71 | BR1_066741 | 41120418 | 38465179 | t | c | 0.424 | 0.580 | 0.342 | 0.568 | 0.167 | 0.729 | 0.396 | 0.359 | 0.260 | 0.848 |
8176278 | 72 | BR1_067978 | 41119181 | 38463942 | a | g | 0.008 | 0.948 | 0.500 | 0.564 | 0.021 | 0.883 | ||||
8066171 | 73 | BR1_068063 | 41119096 | 38463857 | g | t | 0.146 | 0.237 | 0.010 | 0.942 | ||||||
NA | 74 | M_5382insC | 41117845 | 38462606 | - | c | 0.006 | 0.957 | ||||||||
8176289 | 75 | C_2615230 | 41114821 | 38459582 | t | c | 0.441 | 0.566 | 0.342 | 0.568 | 0.223 | 0.258 | 0.396 | 0.359 | 0.266 | 0.808 |
8176293 | 76 | BR1_073023 | 41114136 | 38458897 | a | - | 0.031 | 0.823 | ||||||||
4793192 | 77 | BR1_074008 | 41113155 | 38457916 | a | g | 0.435 | 0.626 | 0.336 | 0.794 | 0.229 | 0.214 | 0.396 | 0.359 | 0.260 | 0.848 |
8176296 | 78 | BR1_074807 | 41112356 | 38457117 | a | g | 0.435 | 0.703 | 0.350 | 0.712 | 0.229 | 0.214 | 0.396 | 0.359 | 0.260 | 0.848 |
3092988 | 79 | C_2615238 | 41110467 | 38455228 | c | t | 0.424 | 0.580 | 0.350 | 0.712 | 0.170 | 0.709 | 0.396 | 0.359 | 0.260 | 0.848 |
8176303 | 80 | BR1_076933 | 41110230 | 38454991 | a | g | 0.010 | 0.942 | 0.042 | 0.763 | ||||||
8176305 | 81 | BR1_077034 | 41110129 | 38454890 | a | g | 0.094 | 0.753 | 0.092 | 0.442 | 0.021 | 0.883 | 0.010 | 0.942 | ||
8176307 | 82 | BR1_077328 | 41109835 | 38454596 | t | c | 0.063 | 0.644 | ||||||||
8068463 | 83 | BR1_079220 | 41107943 | 38452704 | c | t | 0.125 | 0.322 | ||||||||
8176313 | 84 | BR1_079396 | 41107767 | 38452528 | g | a | 0.006 | 0.957 | 0.017 | 0.896 | ||||||
8176316 | 85 | BR1_080570 | 41106594 | 38451355 | c | a | 0.021 | 0.883 | ||||||||
8176318 | 86 | BR1_081125 | 41106039 | 38450800 | g | t | 0.435 | 0.963 | 0.350 | 0.712 | 0.167 | 0.729 | 0.385 | 0.491 | 0.250 | 1.000 |
12516 | 87 | BR1_081990 | 41105173 | 38449934 | c | t | 0.435 | 0.626 | 0.350 | 0.712 | 0.229 | 0.214 | 0.406 | 0.581 | 0.260 | 0.848 |
8176320 | 88 | BR1_082035 | 41105128 | 38449889 | g | a | 0.006 | 0.957 | 0.033 | 0.789 | 0.010 | 0.942 | ||||
8176321 | 89 | BR1_082199 | 41104964 | 38449725 | g | a | 0.010 | 0.942 | ||||||||
8176323 | 90 | BR1_082687 | 41104476 | 38449237 | c | g | 0.429 | 0.766 | 0.350 | 0.712 | 0.229 | 0.214 | 0.396 | 0.359 | 0.260 | 0.848 |
7223952 | 91 | C_11621012 | 41103649 | 38448411 | t | c | 0.441 | 0.566 | 0.356 | 0.765 | 0.281 | 0.569 | 0.396 | 0.359 | 0.287 | 0.931 |
9911630 | 92 | C_3178665 | 41097108 | 38441868 | a | g | 0.422 | 0.429 | 0.364 | 0.926 | 0.266 | 0.808 | 0.396 | 0.359 | 0.283 | 0.813 |
11460963 | 93 | C_2615245 | 41090062 | 38435121 | - | g | 0.441 | 0.497 | 0.350 | 0.712 | 0.228 | 0.242 | 0.396 | 0.359 | 0.266 | 0.808 |
2298861 | 94 | C_3178699 | 41085596 | 38430357 | g | a | 0.441 | 0.309 | 0.350 | 0.712 | 0.223 | 0.258 | 0.396 | 0.359 | 0.266 | 0.808 |
2298862 | 95 | C_3178698 | 41085453 | 38430214 | t | c | 0.447 | 0.383 | 0.350 | 0.712 | 0.208 | 0.343 | 0.396 | 0.359 | 0.260 | 0.848 |
443759 | 96 | C_2287905 | 41074499 | 38419260 | c | t | 0.229 | 0.129 | 0.241 | 0.656 | 0.354 | 0.520 | 0.083 | 0.208 | 0.146 | 0.981 |
11871636 | 97 | C_11617231 | 41063582 | 38408343 | a | c | 0.235 | 0.304 | 0.259 | 0.386 | 0.302 | 0.345 | 0.167 | 0.083 | 0.135 | 0.278 |
2271539 | 98 | C_1588447 | 41059714 | 38404475 | a | g | 0.388 | 0.932 | 0.388 | 0.339 | 0.213 | 0.447 | 0.448 | 0.341 | 0.277 | 0.768 |
690971 | 99 | C_765227 | 41025330 | 38370091 | g | t | 0.281 | 0.885 | ||||||||
528854 | 100 | C_1588417 | 41006873 | 38351634 | a | g | 0.106 | 0.230 | 0.098 | 0.488 | 0.479 | 0.990 | 0.063 | 0.644 | ||
323495 | 101 | C_1588405 | 40983252 | 38328013 | g | a | 0.316 | 0.182 | 0.342 | 0.568 | 0.208 | 0.001 | 0.396 | 0.135 | 0.443 | 0.407 |
2593595 | 102 | C_3256885 | 40965010 | 38309771 | a | g | 0.124 | 0.007 | 0.054 | 0.672 | 0.156 | 0.002 | 0.135 | 0.883 | 0.177 | <.0001 |
324075 | 103 | C_3256881 | 40935288 | 38280049 | a | g | 0.171 | 0.717 | 0.195 | 0.063 | 0.115 | 0.370 | 0.156 | 0.365 | 0.330 | 0.558 |
2290041 | 104 | C_15883310 | 40856085 | 38200846 | c | t | 0.012 | 0.913 | 0.302 | 0.103 | 0.031 | 0.823 | ||||
1078523 | 105 | C_2160077 | 40821525 | 38166286 | a | g | 0.480 | 0.158 | 0.370 | 0.650 | 0.135 | 0.883 | 0.478 | 0.369 | 0.474 | 0.075 |
752313 | 106 | C_1075621 | 40810589 | 38155350 | t | c | 0.363 | 0.314 | 0.422 | 0.851 | 0.292 | 0.954 | 0.406 | 0.250 | 0.351 | 0.251 |
7359598 | 107 | C_3256867 | 40806234 | 38150996 | c | t | 0.386 | 0.073 | 0.440 | 0.674 | 0.135 | 0.883 | 0.438 | 0.486 | 0.383 | 0.243 |
2271027 | 108 | C_15959277 | 40779567 | 38124328 | c | t | 0.065 | 0.636 | 0.031 | 0.823 | ||||||
7214055 | 109 | C_1441435 | 40761936 | 38106697 | c | g | 0.149 | 0.109 | 0.008 | 0.948 | 0.385 | 0.003 | 0.031 | 0.823 | 0.021 | 0.882 |
9766 | 110 | C_1441436 | 40761606 | 38106367 | g | a | 0.353 | 0.219 | 0.433 | 0.700 | 0.292 | 0.954 | 0.406 | 0.250 | 0.344 | 0.823 |
1553469 | 111 | C_7529639 | 40751527 | 38096288 | a | c | 0.065 | 0.248 | 0.058 | 0.061 | 0.031 | <.0001 | 0.202 | 0.943 | ||
2271029 | 112 | C_1125369 | 40744687 | 38089448 | c | a | 0.405 | 0.009 | 0.350 | 0.444 | 0.375 | 0.441 | 0.385 | 0.937 | 0.402 | 0.117 |
3760384 | 113 | C_1441438 | 40744216 | 38088977 | a | c | 0.359 | 0.020 | 0.392 | 0.666 | 0.447 | 0.716 | 0.385 | 0.937 | 0.458 | 0.023 |
2292749 | 114 | C_1441444 | 40727349 | 38072110 | c | t | 0.217 | 0.219 | 0.383 | 0.518 | 0.192 | 0.794 | 0.375 | 0.878 | 0.128 | 0.316 |
Number of polymorphic loci | 83 | 80 | 99 | 71 | 82 | |||||||||||
Number of SNPs with maf<0.05 | 11 | 13 | 14 | 6 | 17 | |||||||||||
Mean maf | 0.305 | 0.269 | 0.181 | 0.327 | 0.287 |
a April 2003 (Build 33) Position
b March 2006 (Build 36.1) Position
c Com Allele = Common allele
d Min Allele = Minor allele
e maf = Minor allele frequency
f Population private SNPs are shown underlined
gNA= Not Applicable – not in dbSNP