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Effects of constitutive activation or inhibition of MAPK on reconstituted epidermis. Human keratinocytes infected with puro (a and d), MAPKK1 (b and e), or MANA (c and f) were cultured for 11 (a–c) or 14 (d–f) days on dead, de-epidermized dermis. Asterisks in d indicate cells in granular layer. Scale bar: 100 μm.
