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. 2001 Aug 15;108(4):591–599. doi: 10.1172/JCI12837

Figure 8.

Figure 8

Immunization after ISCI with a modified MBP peptide promotes functional recovery in EAE-resistant SPD rats. (a) Six SPD male rats were immunized, immediately after spinal cord contusion, with A96 peptide (100 μg/rat) in CFA (containing 0.5 mg/ml bacteria), and six littermates were injected with PBS in the same adjuvant. Rats immunized with A96 recovered significantly better than PBS-injected controls (P < 0.05, two-way ANOVA with replications; *P < 0.05, two-tailed Student’s t test). Mean maximal locomotor score was 7 ± 0.96 in the A96-vaccinated rats (n = 5), 3.9 ± 0.45 in the PBS-CFA–injected rats (n = 5), and 3.0 ± 0.8 in the PBS-injected rats (n = 6, data not shown in the figure). (b) Immunization of SPD male rats (n = 5), immediately after spinal cord contusion, with A96 peptide (500 μg/rat) in CFA (containing 0.5 mg/ml bacteria) had a significant negative effect on functional recovery (P < 0.05, two-way ANOVA with replications).