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. 2007 Sep 18;35(18):6311–6321. doi: 10.1093/nar/gkm650

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© 2007 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Remodelling complexes mobilize nucleosomes off RSSs. A sliding assay on mono-nucleosomes reconstituted onto fragments carrying a 12-RSS using recombinant ACF and ISWI is shown. FM210 has a nucleosome positioned over the RSS in the middle of the fragment whereas MAB5 has a nucleosome positioned over the RSS at the left end of the fragment. Preferential sliding of nucleosomes by ACF from the end of the DNA fragment to the middle and vice versa for the purified catalytic subunit, ISWI, has been demonstrated previously (54). Similar mobilization from the end position to the middle position was also observed using CHRAC, a second ISWI-containing remodelling complex isolated from Drosophila extracts (data not shown).