Table 3.

Helicase motif IV is specifically involved in oligonucleotide binding

Residue numbers in Motif IV	Sequences	Interactions
PcrA (355–365)	AVLYRTNAQSR	R359 binds DNA and forms a salt bridge to E600; N361 interacts with ssDNA and R365 close to dsDNA
Rep (346–356)	AILYRGNHQSR	R350, N352, H353 and R356 interact with ssDNA
RecQ (237–258)	KSGIIYCNSRAKVEDTAAR	R246 equivalent to R365 of PcrA
BLM (898–907)	DSGIILCLSRRECDTMADT	R898 and R899 equivalent to N361 and R365 of PcrA, respectively
HCV(365–372)	LIFCHSKK	K371 interacts with ssDNA
DEAD-box Vasa (493–500)	IVFVETKR	E497 and K499 interact with ssRNA