Table I.
Model variables and their abbreviations.
| Variable | Abbreviation |
|---|---|
| Concentration of A | [A] |
| A·B | Binding of A and B |
| Ascorbate | Asc |
| Iron | Fe2+, Fe3+ |
| Prolyl hydroxylases | PHD2 |
| Hypoxia inducible factor hydroxylated | H IF1αh |
| HIF1α unhydroxylated | HIF1α |
| von Hippel Lindau | VHL |
| Succinate | SC |
| Succinate dehydrogenase | SDH |
| Carbon dioxide | CO2 |
| 2-oxoglutarate | 2OG |
| Oxygen | O2 |
| Elongin B | EB |
| Elongin C | EC |
| Cullins 2 | Cul2 |
| Hydrogen peroxide | H2O2 |
| Dehydro-ascorbate | dehydroAsc |
| Start time for HIF1α synthesis (hrs) | tHIF1α |
| Start time for PHD2 synthesis (hrs) | tPHD2 |
| Reverse rate for PHD2 complex binding to HIF1α (min−1) | koff,HIF1α |
| Reverse rate for PHD2 complex binding to HIF1α, incorporating SC (min−1) | k′off,HIF1α |
| Kinetic term relating O2 to SC levels (min−1) | kSC |
| Production constant for HIF1α (μM·min−1) | kprod,HIF1α |
| Production constant for HIF1α (min−1) | k′prod,HIF1α |
| Production constant for PHD2 (unitless) | kprod,PHD2 |
| Production constant for PHD2 (unitless) | k′prod,PHD2(t) |
| Synthesis term for HIF1α (μM·min−1) | qprod,HIF1α |
| Synthesis term for PHD2 (μM·min−1) | qprod,PHD2 |
| Synthesis term for PHD2 (μM·min−1), case 2 | q1prod,PHD2 |
| Synthesis term for PHD2 (μM·min−1), case 2 | q2prod,PHD2 |