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Inhibition of p38 increases cell volume. Cell volume was measured in the presence or absence of p38 inhibitor using a Coulter Multisizer. Compared with control, acute inhibition of p38 with SB203580 (500 nM) resulted in a rapid initial increase in cell size (5.8 ± 0.1%, n = 5, P < 0.01), reaching a maximum at 5 minutes. This was followed by a gradual return to basal values by 30 minutes.
