Figure 2.

Times to thrombosis after arterial injury. FeCl₃ was used to induce carotid artery injury in WT and ob/ob mice. Displayed from left to right are the results obtained using WT mice, untreated ob/ob mice, ob/ob mice injected with sterile water (Vehicle), and ob/ob mice after intraperitoneal administration of either 0.06 mg/kg (Low leptin) or 0.6 mg/kg (High leptin) body weight. The horizontal lines represent the median of the displayed values in each group. For statistical analysis, mice that only transiently occluded or did not occlude completely after injury are represented at the top of the graph as having times to thrombosis that correspond to the end of the flow-monitoring period (25 minutes).