Table 1 Main characteristics and functional variables of study subjects.
| Controls (n = 6) | Patients with OSAS before treatment (n = 12) | Patients with OSAS after treatment (n = 12) | |
|---|---|---|---|
| Age (years) | 43.5 (13) | 43 (10) | 43 (11) |
| BMI (kg/m2) | 33.9 (6.2) | 35.9 (8) | 34.3 (6) |
| AHI (events/h) | 4 (1.5) | 78 (41.2)*** | 3 (3.8)††† |
| Mean Sao2 (%) | 95 (3.5) | 85 (7.5)*** | 94 (4)††† |
| Nadir Sao2 (%) | 92 (5) | 70 (26.5)*** | 88 (5)††† |
| Time Sao2 <90% (%) | 1 (3.5) | 74 (22.5)*** | 1 (15)††† |
| CPAP (cm H2O) | – | – | 9 (3.5) |
| CPAP time (h) | – | – | 5 (1.2) |
| ESS score | 5.5 (5.2) | 16 (5.5)*** | 9.5 (7.2)††† |
| FEV1 (% pred) | 93 (28) | 95 (11) | 99 (12) |
| FVC (% pred) | 93 (24) | 111 (20) | 111 (15) |
| FEV1/FVC (%) | 80 (6) | 75 (7) | 73 (3) |
| FRC (% pred) | NA | 87 (19) | 96 (20) |
| Tlco (% pred) | NA | 118 (36) | 125 (41) |
| Pao2 (mm Hg) | 74 (8) | 74 (15) | 78 (12) |
| Paco2 (mm Hg) | 40.1 (5) | 41.5 (3.1) | 39.6 (2.9) |
| MIP (% pred) | N.A. | 91 (21) | 108 (33) |
| Tlim (min) | 9.5 (1.6) | 3.2 (4.3)*** | 2.1 (0.2) |
| Handgrip, (% pred) | NA | 115 (69) | 131 (72) |
| 6‐min walking distance (% pred) | NA | 92 (13) | 90 (19) |
| Type I fibres (%) | 48 (11) | 57 (15)* | 41 (27)†† |
| Type II fibres (%) | 52 (11) | 43 (15)* | 59 (27)†† |
| Type I fibre area (μm2) | 1813 (1018) | 2206 (585) | 1970 (266) |
| Type II fibre area (μm2) | 2219 (1005) | 2206 (1079) | 2463 (633) |
Data are presented as median (interquartile range).
BMI, body mass index; Sao2, arterial oxygen saturation; CPAP, continuous positive airway pressure; ESS, Epworth Sleepiness scale; FEV1, forced expiratory volume in 1 s; pred, predicted; FVC, forced vital capacity; FRC, functional residual capacity (as expressed by intrathoracic gas volume); Tlco, carbon monoxide transfer factor; MIP, maximal inspiratory pressure, Tlim, endurance time.
*p⩽0.05, **p⩽0.01, ***p⩽0.001 control subjects vs OSAS patients before treatment.
†p⩽0.05, ††p⩽0.01, †††p⩽0.001 OSAS patients before vs after treatment.