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. 2007 Nov 23;3(11):e180. doi: 10.1371/journal.ppat.0030180

Figure 4. Mutational Pathways to Virulence within Codon 48 of the VPg.

Figure 4

Mutational pathway I was shared by all strains with the notable exception of strain S2/S3. It involved two successive transitions (ti) from the wild arginine coded by codon AGA. Mutational pathway II was isolate-specific (CI4) and involved two successive transversions (tv). The dotted arrow indicates that V48 arose but did not replace I48. Mutational pathway III was specific for isolate Ma203 of the S2/S3 strain, with the wild arginine coded by codon AGG. It involved a single transversion.