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. 2007 Dec 5;2(12):e1257. doi: 10.1371/journal.pone.0001257

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Dheekollu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) Schematic of EBV episome DNA replication with fork pausing and terminating at OriP. Recombination structures are formed at OriP and provide sister chromatid cohesion through topological linkages. Resolution of these linkages in anaphase promotes genome segregation and stable plasmid maintenance. B) Speculative model showing MRN and recombination structures that may form at DS. These include strand invasion, double Holliday junctions, and hemicatenane of nascent strand DNA.