Table 1.

Epidemiology studies examining the prevalence of co-occurring SUDs in bipolar disorder.

Epidemiological Study	Number of subjects	Lifetime prevalence of co-occurring SUDs in bipolar I (or combined total if type not specified)	Lifetime prevalence of co-occurring SUDs in bipolar II
NESARC [2]	General Population; 43,093 subjects	58% for alcohol use disorders; 38% for drug use disorders
National Institutes of Mental Health Epidemiologic Catchment Area Program [5]	General Population; 20,291 subjects	61% for any SUD	48% for any SUD
Cassidy et al. [6]	392 bipolar I patients	48.5% for alcohol abuse; 24.2% for cocaine abuse; 4.6% for opioid abuse; 36% for cannabis abuse.
McElroy et al. [7]	239 bipolar I; 49 bipolar II	36% for alcohol abuse; 10% for cocaine abuse; 8% for opioid abuse; 40% for cannabis abuse.	22% for alcohol abuse; 4% for cocaine abuse; 0% for opioid abuse; 10% for cannabis abuse.
Chengappa et al. [35]	71 bipolar I; 18 bipolar II	57.8% for alcohol abuse; 11.3% for cocaine abuse; 5.6% for opioid abuse; 19.7% for cannabis abuse.	38.9% for alcohol abuse; 5.6% for cocaine abuse; 0% for opioid abuse; 5.6% for cannabis abuse.
The University of Cincinnati First-Episode Mania Study [14, 15]	144 bipolar I	42% for alcohol abuse; 46% for cannabis abuse
The McLean-Harvard First-Episode Mania Study [9]	112 bipolar I	33% for any SUD during the index affective episode
Veterans Affairs (VA) Cooperative Study #450 [10]	328 bipolar I and II patients (analyzed together)	61.9% for alcohol abuse; 19.5% for cocaine abuse; 8.5% for opioid abuse; 22.6% for cannabis abuse