Table 2.

Treatment studies of bipolar disorder with co-occurring SUDs.

Treatment Study	Design	Treatment	Number of patients	SUD	Results
Geller et al. [28]	double-blind placebo-controlled	Lithium	12 bipolar I; 5 bipolar II	Alcohol or drug dependence	Improvement in affective and SUD symptoms
Salloum et al. [46]	double-blind placebo-controlled	Valproate (as adjunct to lithium)	59 bipolar I	Alcohol dependence	Improvement in SUD but not affective symptoms
Brown et al. [27]	Open-label	Aripiprazole	18 bipolar I; 1 bipolar II; 1 schizoaffective disorder, bipolar type	Alcohol or drug abuse or dependence	Improvement in affective and SUD symptoms
Brown et al. [45]	Open-label	Lamotrigine	22 bipolar I; 7 bipolar II; 1 bipolar NOS	Cocaine dependence	Improvement in affective and SUD symptoms
Brown et al. [26]	Open-label	Quetiapine	14 bipolar I; 3 bipolar II	Cocaine dependence	Improvement in affective symptoms but not SUD symptoms
Brown et al. [44]	Open-label	Naltrexone	34 bipolar (type?)	alcohol dependence	Improvement in affective and SUD symptoms
Drake et al. [47]	Open-label	Integrated dual disorder treatment	51 bipolar (type unspecified)	Alcohol or drug abuse or dependence	Improvement in SUD but not affective symptoms
Schmitz et al. [33]	Open-label	Cognitive therapy as an adjunct to medication	46 bipolar (type unspecified)	Alcohol or drug abuse or dependence	Improvement in affective symptoms but not SUD symptoms
Weiss et al. [34]	Open-label	Integrated group therapy	50 bipolar I; 10 bipolar II; 2 bipolar NOS	Alcohol or drug dependence	Improvement in SUD but not affective symptoms