TABLE 7.

Frequency of occurrence of adverse effects with linezolid, vancomycin and quinupristin/dalfopristin (Q/D) in controlled, clinical trials

Adverse effect	Linezolid (n=2046)	Vancyomycin	Q/D
Diarrhea	+++	+	+
Headache	+++	+	+
Nausea	+++	+	++
Vomiting	++	+	+
Insomnia	++	+	+
Constipation	++	+	+
Rash or allergic	++	++	+
Dizziness	++	+	+
Fever	+	+	+
Taste alteration	+	-	+
Vaginal moniliasis	+	+	+
Abnormal liver function tests	+	-	++
Tongue discoloration	+	-	-
Arthralgia	-	-	+++
Myalgia	-	-	+++
Venous events	+	+	+++
Nephrotoxicity	-	+	-
Ototoxicity	-	+	-

Comparators included: clarithromycin, cefpodoxime, ceftriaxone, dicloxacillin, oxacillin and vancomycin. + Less than 2%; ++ 2% to 5%; +++ 5% to 6.5%. Adapted from references 38-40,50,82