TABLE 6.
Comparison of adverse drug reactions associated with some approved fluoroquinolones (%)
| Reaction | Levofloxacin | Gatifloxacin | Moxifloxacin | ||||
|---|---|---|---|---|---|---|---|
| Reference | PI | 50* | 51 | 31 | 30* | 51 | 52 |
| No patients | NR | 2252 | 1655 | 15,625 | 6170 | 6500 | 18,409 |
| Nausea | 7.1 | 9 | 2.8 | 4 | 8 | 0.3 | 5.7 |
| Diarrhea | 5.6 | 4 | 1.7 | 1.4 | 6 | 0.9 | 2.4 |
| Headache | 6.4 | 4 | 0.5 | 0.9 | 2 | 0.1 | <2 |
| Vomiting | 2.2 | 2 | 0.6 | 0.7 | 2 | 0.2 | <1 |
| Vaginitis | 1.6 | 5 | <1 | <1 | <1 | NI | <1 |
| Dizziness | 2.9 | 3 | 1.3 | NR | 3 | 0.3 | 2.3 |
| Taste perversion | 1.0 | 2 | 0.8 | 0.5 | <1 | NR | <1 |
| Discontinuations | 3.4 | 3.2 | NR | 3.1 | NR | NR | NR |
*
Clinical trial programs. PI Package Insert trial data; NI No incidence; NR Not reported