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. 2001 Oct 15;108(8):1151–1158. doi: 10.1172/JCI11494

Figure 4.

Figure 4

Experimental BP in MC-deficient mice reconstituted with normal PMNs. Pathogenic rabbit anti-mBP180 IgG (intradermal injection, 2.5 mg/g body weight) induced skin blisters in MC-sufficient (+/+) mice (a) and toluidine blue staining showed the presence of MCs (b). Anti-mBP180 IgG failed to trigger the skin lesions in MC-deficient MgfSl/MgfSl-d mice (c), but R621 IgG triggered the skin disease in MgfSl/MgfSl-d mice reconstituted with PMNs from MC+/+ mice (e) or MC-deficient mice (data not shown). Toluidine blue staining confirmed the MC deficiency in these animals (d and f).