Table 1.
Telomere and telomerase associated proteins and their inhibitors
| Description | Inhibitors | References | |
|---|---|---|---|
| Telomerase components | |||
| hTERT | Human telomerase reverse transcriptase | AZT B1BR1532 Vaccine |
Strahl, 1996 Damm, 2001 Carpenter, 2006 |
| hTERC | Human telomerase RNA component | 2-5A antisense GRN163L GDEPT |
Kondo, 1998 Dikmen, 2005 Plumb, 2001 |
| Hsp90 | Heat shock 90 kDa protein | 17-AAG, 17-DMAG | Holt, 1999 |
| TP1 | Telomerase-associated protein 1 | NK | Keith, 2002 |
| Telomere proteins | |||
| TRF1 | Telomeric-repeat-binding factor 1 | NK | VanSteensel, 1997 |
| TRF2 | Telomeric-repeat-binding factor 2 | NK | Karlseder, 1999 |
| Tankyrase | Tankyrase, TRF1-interacting ankyrin-related poly(ADP-ribose) polymerase (PARP) | 3-aminobenzamide ABT-888 AG14361 |
Seimiya, 2005 Donawho, 2007 Thomas, 2007 |
| TIN2 | TRF1-interacting protein 2, negative regulator of telomere length | NK | Keith, 2002 |
| POT1 | Telomere-end-binding protein 1 | Telomestatin BRAC019 RHPS4 |
Gomez, 2006 Kelland, 2005 Salvati, 2007 |
| Dykserin | Catalyzes pseudouridylation, is associated with hTERC, has structural function | NK | Mochizuki, 2004 |
| Telomere repair | |||
| MRE11 | Meiotic recombination 11 homologue | NK | Blasco, 2003 |
| RAD50 | Rad50 (S. cerevisiae) homologue | NK | Blasco, 2003 |
| KU70 | Thyroid autoantigen 70 kDa (Ku antigen) | NK | Blasco, 2003 |
| XRCC5/KU80 | X-ray repair (double-strand-break rejoining; Ku autoantigen, 80 kDa) | NK | Blasco, 2003 |
| H2AX | Histone 2 AX | RHPS4 (induction of γ-H2AX) |
Phatak, 2007 Salvati, 2007 |
NK, not known; references list only the first author and year of publication.