Figure 3.
Effect of antioxidants on concentration-dependent contractions to A23187 in femoral arteries with endothelium from STZ-treated rats in the presence of L-NAME. (a) Tiron and SOD, n=8–10, (b) deferoxamine, catalase and DETCA; n=12–20 and (c) MnTMPyP; n=8. Data are expressed as percentage of the reference contraction to 60 mM KCl and are shown as means±s.e. mean; *Significant difference (P<0.05) from the controls (rings with endothelium). DETCA, diethyldithiocarbamic acid; L-NAME, Nω-nitro-L-arginine methyl ester hydrochloride; MnTMPyP, Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin pentachloride; SOD, superoxide dismutase; STZ, streptozotocin.