Figure 5.
Tachycardia remodelling of IKM4. (a) Representative IKM4 recordings obtained with protocol shown in inset in left atrial control and ATP cardiomyocytes. (b) Mean±s.e.m. current density–voltage relationships of IKM4 in control and ATP cardiomyocytes isolated from left atria (LA) and PVs. (n=24, 23, 14, and 26 cells in LA control, LA ATP, PV control and PV ATP, respectively. *P<0.01, **P<0.001). ATP, atrial tachypaced; IKM4, M4 receptor-mediated inward rectifier K+ currents; PV, pulmonary vein.