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. 2007 Sep 17;152(7):1092–1101. doi: 10.1038/sj.bjp.0707460

Figure 8.

Figure 8

Activation of GPR55 leads to activation of rhoA, cdc42 and rac1. Cells transfected with GPR55 demonstrated O1602-(1 μM) and anandamide (1 μM)-mediated activation of the small G proteins rhoA, cdc42 and rac1 while the non-GPR55-activating ligand WIN55,212-2 had no effect. The activation was blocked by cannabidiol (10 μM) while the positive control GTPγS and negative controls (GDP and dimethyl sulphoxide ) generated the expected responses. The blots shown are representative of three independent experiments.