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Profile of antagonist activities of ligands at GPR55, CB1 and CB2 receptors
| Ligand | GPR55 IC50 (nM) GTPγS binding | CB1 IC50 (nM) GTPγS binding | CB2 IC50 (nM) GTPγS binding |
|---|---|---|---|
| Cannabidiol | 445±67 | >30 000 | >30 000 |
| Cannabinol | >30 000 | >30 000 | >30 000 |
| AM281 | >30 000 | 7±0.6 | 2600±463 |
| AM251 | Agonist | 8±1 | 2915±102 |
| WIN55,212-2 | >30 000 | Agonist | Agonist |
Data obtained using an EC80 concentration of CP55940 as agonist for each receptor. Values shown are the means±s.e.m. derived from five independent experiments.
