Figure 3.

Desensitization of the Hp(2–20) (50 μM) response. Monocytes first activated with the agonist WKYMVm (0.1 μM) (which desensitizes FPR, FPRL1 and FPRL2) were unable to generate a second burst of superoxide when challenged 10 minutes later with Hp(2–20) (a). Homologous desensitization with two subsequent stimulations of Hp(2–20) was also apparent (b). No desensitization against Hp(2–20)–induced activation was obtained in monocytes first challenged with fMLF (0.1 μM) (which desensitizes only FPR) (c).