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Figure 4 DNA methylation and histone acetylation regulate leptin expression in normal chondrocytes. (A) Treatment with 5 μM AZA for 5 days increased leptin expression seven fold, while 1 μM TSA for 1 day's treatment increased leptin expression six fold. AZA and TSA treatment had a synergistic effect (14‐fold) in leptin expression levels. (B) After TSA treatment, H3 K9/14 was found to be acetylated in the leptin promoter.
