Figure 4 APC inhibiting the activation of NF‐κB in monocytes. The active form of NF‐κB in whole cell lysates of monocytes was detected by western blotting using an antibody against active NF‐κB. RA monocytes were treated with no test agent (C), LPS (100 ng/ml), LPS plus APC (20 μg/ml) in the presence or absence of RCR252 (R252, 10 μg/ml) or RCR92 (R92, 10 μg/ml). Images were semiquantified using image‐analysis software. Data are expressed as mean (SEM) (n = 3) % of control (no treatment). **p<0.01.