Table 4 Combined results from randomised clinical trials examining the absolute change in specific signs and symptoms after topical treatment versus placebo.

Clinical variable	No of studies	SMD	95% CI	p Value	Publications
Total signs	3	−0.94	−1.34 to −0.54	<0.001	10,17,34
Total symptoms	3	−0.73	−1.14 to −0.32	<0.001	10,17,34
Itching	6	−1.43	−1.76 to −1.1	0.001	12,16,18,25,28,31
Tearing	4	−0.84	−1.2 to −0.49	<0.001	16,18,28,31
Photophobia	4	−0.27	−0.59 to 0.06	0.105	16,18,28,31
Tarsal papillae	4	−0.32	−0.64 to 0	0.047	11,16,28,31
Corneal involvement	5	−1.15	−1.5 to −0.8	<0.001	11,12,16,18,31
Limbal disease	5	−1.17	−1.50 to −0.83	<0.001	11,16,18,28,31
Hyperaemia	6	−1.07	−1.38 to −0.76	<0.001	12,16,18,25,28,31

SMD, standardised mean difference.