Figure 2 Gene expression in Epstein–Barr virus (EBV) associated Hodgkin lymphoma. (A) EBER expression (brown staining) in the nuclei of Hodgkin/Reed–Sternberg (HRS) cells. In situ hybridisation for EBER expression is the most reliable and sensitive method to detect the presence of latent EBV infection in clinical samples. (B) The latent membrane protein‐1 (LMP1) and (C) LMP2 are both highly expressed in EBV‐positive HRS cells. Not shown is the consistent expression of the EBV maintenance protein, EBNA1.